O togafitiga alopecia e faʻasaoina ai le 80% o lauulu

A HOLD Fa'asa'oloto 7 | eTurboNews | eTN
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Tagata matutua e ogaoga alopecia areata (AA) o le na ave le OLUMIANT® (baricitinib) na ausia le taua tele o le ulu, fulufulu mata ma le fulufulu mata ma toetoe lava 75% oi latou na tali atu i le OLUMIANT 4-mg na ausia le 90% o le paʻu o le ulu ile 52 vaiaso, Eli Lilly ma Kamupani ma Incyte faʻasalalau i aso nei. i le American Academy of Dermatology (AAD) Fonotaga Faaletausaga. Ia Fepuari 2022, na tu'uina atu ai e le US Food and Drug Administration (FDA) le fa'amuamua o le iloiloga mo le OLUMIANT i le AA tuga e avea o se vaila'au muamua-i-ma'i. O loʻo faʻamoemoeina e Lilly faʻaiuga faʻatonutonu i le US, Europa Europa ma Iapani i le 2022.

I le su'esu'eina o le 52-vaiaso, o tagata mama'i i le laina fa'avae sa i ai le uiga o le mamafa o Meafaigaluega Alopecia (SALT) togi o le 85.5 (85.5% le pa'u o le ulu o le ulu, po'o le 14.5% le ufiufi o lauulu ulu); ogaoga AA o loʻo faʻamatalaina o le maua o le SALT score ≥50 (≥50% paʻu lauulu lauulu). I le laina fa'avae, 69.4% ma le 57.9% na matua'i gau fulufulu mata ma fulufulu mata, e pei ona fa'amatalaina e le Clinician-Reported Outcome (ClinRO) scores ≥2. O le averesi o tausaga o ma'i e 37.6 tausaga, faatasi ai ma le gau o lauulu e amata ile 25 tausaga ma le fua o le 12.2 tausaga talu ona amata fa'ailoga.

Faatasi ai ma tagata gasegase na ave le OLUMIANT 4-mg, lua mai le lima (39.0%, n = 201/515) na ausia le toe faʻaleleia o lauulu lauulu, faʻamatalaina o le SALT score ≤20, poʻo le 80% poʻo le sili atu o le ulu ulu ulu, ma toetoe lava tolu mai fafo. o le toafa o na gasegase (74.1%, n = 149/201) na ausia foi le SALT score ≤10, poʻo le 90% lauulu lauulu, ile 52 vaiaso. E ese mai, e sili atu i le lua mai le lima tagata mamaʻi ma ClinRO sikoa sikoa ≥2 (matamata: 44.1%, n = 154/349; laumata mata: 45.3%, n = 139/307) na vaʻaia le toe faʻaleleia atoa poʻo le toe faʻaleleia ma le vaʻa itiiti i laumata ma laumata. lauulu.

Faatasi ai ma tagata gasegase na ave le OLUMIANT 2-mg, e sili atu ma le tasi mai le lima (22.6%, n = 77/340) na ausia le toe faʻaleleia o lauulu lauulu ma le lua mai le tolu o na gasegase (67.5%, n = 52/77) ausia 90 % pe sili atu le ufiufi o lauulu ile 52 vaiaso. E ese mai, e sili atu ma le tasi i le lima ma le tasi i le fa maʻi, i le faasologa (matamata: 22.9%, n = 55/240; laumata mata: 25.5%, n = 51/200), na vaʻaia le toe faʻaleleia atoa poʻo le toe faʻaleleia ma le itiiti o va i mata ma mata. lauulu.

O nei suʻesuʻega faʻapipiʻi 52-vaiaso o loʻo faʻaalia ai le faʻaauau pea o le faʻaleleia o le ulu, fulufulu mata ma le fulufulu mata mai le 36-vaiaso iʻuga na lomia i le aso nei i le New England Journal of Medicine ma tuʻuina atu i le 2021 European Academy of Dermatology and Venereology (EADV) Congress.

"Pe o tagata e maua i le alopecia areata e mafatia i le toesea uma o lauulu i luga o latou tino poʻo ni lanu tula ma le misia o mata mata poʻo fulufulu mata, o lenei faʻamaʻi autoimmune e mafai ona faʻaleagaina. O le faʻamaʻi e aʻafia ai tagata o vaitausaga uma, "o le tala lea a Brett King, MD, Ph.D., FAAD, polofesa lagolago o dermatology i le Yale School of Medicine ma le tusitala taʻitaʻi o nei suʻesuʻega. "I le 2022, o le OLUMIANT e mafai ona avea ma vailaʻau muamua na faʻatagaina e togafitia ai tagata matutua e maua i le alopecia areata. E ofoofogia le toeitiiti atoa le 40% o tagata mamaʻi ile OLUMIANT 4-mg, oi latou uma na amata ma le itiiti ifo i le 50% o le paʻu o le ulu o le ulu, na oʻo i le atoatoa poʻo le toeitiiti atoa le paʻu o lauulu, ma faʻalelei tutusa na ausia i na tagata mamaʻi ma mataʻutia mataʻutia. auai.”

I se iloiloga o le OLUMIANT 4-mg ma le 2-mg saogalemu umi, o fua faatatau o faʻalavelave faʻafuaseʻi lipotia e oʻo atu i le 52 vaiaso (median 56 vaiaso faʻaalia) na ogatasi ma le 36-vaiaso, placebo-pulea vaitaimi ma aofia ai le manava pito i luga. fa'ama'i fa'ama'i, ulu ulu, siama, fa'ama'i o le urinary tract ma fa'ateleina fa'ailoga toto e fa'atatau i maso. Sa leai ni faailoilo saogalemu fou.

“O fa'amaumauga a le OLUMIANT mo se taimi umi e fa'aalia ai le toe fa'aleleia o le ulu, fulufulu mata ma fulufulu mata ma e matou te fiafia i le uiga o nei fa'ai'uga mo gasegase. O a matou faʻamaumauga o le saogalemu o le alopecia areata e faʻaopoopo atili ai faʻamaoniga i se tasi o seti sili ona tele ma sili ona umi o faʻamaumauga o le saogalemu i le JAK inhibitor vasega, e aofia ai le iva tausaga ma le 19,000 tausaga faʻamaʻi i la matou polokalame, "o le tala lea a Lotus Mallbris, MD, Ph.D., sui peresitene o le atina'eina o immunology i le lalolagi ma mataupu tau foma'i i Lilly. "Matou te fiafia o le OLUMIANT atonu o se vailaʻau muamua-i-faʻamaʻi faʻamaonia i lenei tausaga mo tagata matutua e ogaoga le alopecia areata."

E uiga i le tusitala

Avatar a Linda Hohnholz

Linda Hohnholz

Faatonu sili mo eTurboNews fa'avae ile eTN HQ.

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