Isleworth Healthcare Acquisition Corp. ma Cytovia Holdings, Inc. i aso nei ua fa'ailoa mai ua latou osia se maliliega tu'ufa'atasiga fa'apisinisi. I le maeʻa ai o lenei tuʻufaʻatasiga, o le a toe faʻaigoaina Isleworth Cytovia Therapeutics, Inc. (le "kamupani tuʻufaʻatasia") ma o ana faʻatauga masani ma tusi saisai e tatau ona tumau i luga o le NASDAQ i lalo o faʻailoga faʻailoga INKC ma INKCW, taʻitasi.
O le kamupani tu'ufa'atasi o le a fa'aauauina galuega a Cytovia ma fa'aauau le taula'i i le atina'eina ma le gaosiga o le NK cell ma le NK engager antibody platforms.
O le kamupani tuʻufaʻatasia o le a taʻitaʻia e Dr. Daniel Teper, le Co-Founder, Taitaifono, ma le Ofisa Sili o Pulega o Cytovia.
"Matou te faʻafetai tele mo le lagolago malosi mai tagata fou ma o loʻo i ai nei teuga tupe ma le 'au o tagata fai pisinisi faʻapitoa i Isleworth. Matou te faʻamoemoe o lenei fefaʻatauaʻiga e faʻavavevave ai le faʻatinoina o le vaʻaiga a Cytovia e faʻalauteleina togafitiga NK mo se fofo mo le kanesa” o le tala lea a Dr. Teper. "Ua faʻamalosia i matou e a matou faʻamatalaga faʻapitoa na tuʻuina atu talu ai nei i le AACR, lea e lagolagoina ai le faʻalauteleina o le atinaʻeina o matou iPSC e maua mai i le NK sela (iNK) ma Flex-NK ™ cell engagers mo togafitiga o le Hepatocellular Carcinoma."
O Bob Whitehead, le Pule Sili o Isleworth, fai mai: “Na iloiloina e Isleworth le tele o kamupani faasaienisi o le olaga ma sa sili ona faagaeetia i taleni ma tekinolosi na tuufaatasia e Cytovia. Matou te talitonu o Cytovia o se tasi o kamupani sili ona maualuga, faʻafouga faʻafomaʻi sela o loʻo aʻafia i le atinaʻeina o togafitiga fou o le kanesa. O togafitiga sela i le oncology ua uma ona aumaia le faamoemoe i le faitau miliona. O auala a Cytovia e mafai ona faʻaogaina auala tutusa e sili atu ona faigofie 'le-le-fata' ma taugofie.
Cytovia's Therapeutic Approach
Cytovia faʻamoemoe e faʻavavevave le avanoa o tagata maʻi i togafitiga faʻafouga ma le immunotherapies, faʻatalanoaina le tele o manaʻoga faʻafomaʻi sili ona luʻitau ile oncology.
O loʻo taulaʻi le kamupani i le faʻaogaina o le faʻaogaina o le immune system e ala i le atinaʻeina o le NK-cell ma le NK-engager antibody platforms faʻapitoa ma faʻalavelave. Aemaise lava, o Cytovia o loʻo atinaʻeina ituaiga e tolu o sela iNK: sela iNK e leʻi faʻasalaina, TALEN® faʻasologa o le iNK sela ma faʻaleleia le gaioiga ma le faʻaauau, ma TALEN® gene-edited iNK sela ma chimeric antigen receptors (CAR-iNKs) e faʻaleleia ai le tumo faʻapitoa. tulimata'i. O le tekonolosi maatulimanu fa'aopoopo lona lua o se fa'ailoga fa'ama'i fa'apitoa fa'apitoa e fa'aogaina e fa'aogaina ai sela NK e ala i le fa'atatauina o le NKp46 fa'agaoioi le fa'aogaina e fa'aoga ai le tekonolosi Flex-NK™.
O loʻo faʻaaogaina nei faʻatekonolosi e lua e atiaʻe ai togafitiga mo tagata mamaʻi e maua i le Hepatocellular Carcinoma (HCC) ma tuma maʻa. O su'esu'ega fa'afoma'i e fa'amoemoe e amata i le fa'ai'uga o le 2022.
O le ofisa autu i Aventura, FL, Cytovia o loʻo faʻatautaia fale suʻesuʻe R&D i Natick, MA ma se fale gaosi oloa cGMP i Puerto Rico ma o loʻo i ai faiga faʻasaienisi faʻatasi ma Cellectis, CytoImmune Therapeutics, le Hebrew University of Jerusalem, INSERM, New York Stem Cell Foundation, National Cancer Institute, ma le Iunivesite o Kalefonia San Francisco (UCSF). O le Cytovia Therapeutics e le'i leva ona fausia CytoLynx Therapeutics, o se faiga fa'apa'aga e taula'i i su'esu'ega ma atina'e, gaosiga, ma fa'atauga fa'apisinisi i Saina Tele ma tua atu.
Cytovia Paipa
O Cytovia o le kamupani muamua o le immune-oncology e iai le malosi e tu'ufa'atasia ai le fa'asologa o le iPSC e maua mai i le NK Cell ma le Flex-NK ™ cell engager antibody platforms e atia'e ai le isi augatupulaga o immunotherapies mo tuma toto ma toto.
O le faila a Cytovia e aofia ai sini ma faʻailoga ma se faʻamatalaga paleni tulaga lamatia.
O le GPC3 ose fa'amoemoega tala fou mo tuma malo, aemaise o le kanesa o le hepatocellular, lea e sili ona taua le mana'oga fa'afoma'i e le'i ausia. O le polokalame ta'imua a Cytovia o lo'o fa'amoemoe e atia'e togafitiga HCC muamua ile vasega ole GPC3. O sui muamua e fa o oloa o le a iloiloina o ni monotherapy ma o ni togafitiga tu'ufa'atasi. CYT-303, Cytovia's GPC3 Flex-NK ™ engager, o se antibody e tolu-faapitoa e fusifusia i sela tumo HCC e ala i le GPC3 ma i sela NK e ala i le NKp46 ma le CD16a. Mo tagata mama'i e faaletonu le numera po'o le gaioiina o sela NK, o le a iloilo e Cytovia le fa'aopoopoina o sela o le iNK, CYT-100, ina ia mafai ai ona tatala le gafatia atoatoa o lenei togafiti togafiti. O lo'o fa'atupuina fo'i e Cytovia le CYT-150, sela o le iNK ua fa'asa'oina e gafa, e fa'aleleia atili ai le ulu o le tumo ma le fa'aauauina o sela, e mafai fo'i ona tu'ufa'atasia ma le CYT-303. E le gata i lea, o le CYT-503, o le GPC3-targeting CAR-iNK cell therapeutic, ua mamanuina e faʻaleleia atili ai le faʻapitoa mo le tulimataʻiina o le tuma. Ua faamoemoe Cytovia e faila INDs mo CYT-303 ma CYT-100, sosoo ai ma INDs mo CYT-150 ma CYT-503.
O le CD38 ose falema'i ma fa'atau pisinisi mo Multiple Myeloma. Cytovia o loʻo atiaʻe le CYT-338 ma le CYT-538 o loʻo i ai, i le faasologa, CD38-targeting Flex-NK ™ cell engagers ma CAR-iNK sela mo le togafitiga o le Myeloma Tele i tagata mamaʻi ua le manuia togafitiga faʻamaʻi CD38 ma sui faʻatatau i le matua o le B-cell. antigen (BCMA).
O lo'o fa'atupuina fo'i e Cytovia se sui tauva EGFR CAR iNK intracranial e fa'atatau i le wtEGFR ma le EGFR vIII e fa'atautaia ai se mana'oga fa'afoma'i taua i le puleaina o le Glioblastoma multiforme e le mafai ona togafitia.
Ua fa'avaeina e Cytovia le galulue fa'atasi ma fa'alapotopotoga fa'aa'oa'oga ma pa'aga fa'apisinisi e aofia ai le Cellectis mo le TALEN® gene-editing. O le TALEN® gene-editing ose tekonolosi na paionia ma pulea e Cellectis, o se kamupani biotechnology fa'ata'ita'i fa'ata'ita'i o lo'o fa'aogaina lona fa'asologa o kenera e atia'e ai sela fa'aola ola ma fa'ama'i ga'o. O le TALEN® gene-edited pateni o loʻo pulea e Cellectis i le fanua o iNK ma CAR-iNK ua laiseneina mai Cellectis e Cytovia ma Cytovia o loʻo umia le atinaʻeina o le lalolagi ma aia faʻapisinisi i nei pateni.
Ma'a'a Fuafuaina ma le Fa'aaogaina o Tupe Maua
O tupe maua mai nofoaga tumaoti (le "PIPE"), tupe i totonu o le teugatupe tausi mavaega a Isleworth (fa'ato'a fa'aola), ma tupe maua mai isi fa'atupega fa'amoemoe, i le aofa'iga fa'atasi e o'o atu i le selau miliona tala, o le a maua ai e Cytovia le tupe faavae e o'o atu i le 2. tausaga e fa'atupu atili ai ana fa'ata'ita'iga iNK ma Flex-NK™ fa'atekonolosi fa'afeso'ota'i sela. Ua fuafua Cytovia e taulaʻi atu i le tele o mea taua, e aofia ai:
• Fa'auluina o INDs muamua e lua mo Flex-NK™ CYT-303 ma le iNK CYT-100
• Amataina le Vaega I/II fa'ata'ita'iga fa'apitoa e iloilo ai le CYT-303 ma le CYT-100, na'o le tu'ufa'atasia, mo togafitiga o le HCC
• Mauaina ma le tu'uina atu o fa'amatalaga fa'afoma'i muamua mo le CYT-303 ma le CYT-100 ile HCC
• Fa'aulu INDs mo le CYT-150 ma le CYT-503 ma amataina le Vaega I/II fa'ata'ita'iga fa'apitoa.
• Fa'aauauina le fa'aleleia atili o tekonolosi iNK & Flex-NK™ ma fa'agasolo le paipa fa'atasi ai ma le tele o sui tauva
