O le Ma'i Muamua na Tu'uina ile Ma'i Atete ole Pumu

Respira Therapeutics, Inc. na faasilasilaina i le asō o le tagata muamua na maua i le Iunaite Setete ua faʻataʻitaʻiina i le multicenter faʻataʻitaʻiga o lona sui tauva oloa taʻitaʻia, RT234-PAH (vardenafil faʻatonuina e pei o se paʻu mamago togafitiga inhaled). O le VIPAH-PRN 2b faʻataʻitaʻiga (Vardenafil Inhaled for Pulmonary Arterial Hypertension - PRN) o le a aofia ai ni faʻasologa faʻasolosolo se lua e mauaina le RT234 e pei o tui e tasi e faʻatinoina e ala i le Axial Oscillating Sphere dry powder inhaler. O le suʻesuʻega ua mamanuina e iloilo ai le saogalemu ma le aoga muamua o le RT234 e faʻaleleia atili ai faʻamaoniga episodic ma faʻamalositino malosi i tagata o loʻo togafitia mo le toto maualuga o le pulmonary arterial (PAH) ma New York Heart Association (NYHA) Functional Class II-III symptoms.     

"O le amataina o lenei faʻataʻitaʻiga faʻataʻitaʻiga e fai ma sui o se mea taua tele mo Respira ma o se laasaga taua tele i le tuʻuina atu o tagata mamaʻi i le PAH se togafitiga faʻapitoa e pulea ai le manava manava, lea e taofia ai i latou mai le faia o tiute masani i aso taitasi," o le tala lea a Carol Satler, PhD. , MD, Peresetene ma Fomaʻi Sili o Respira. "O tagata o loʻo mafatia i lenei tulaga faʻavaivaia ma ogaoga o loʻo togafitia i togafitiga faʻaleleia o loʻo feagai pea ma vaega o le manava, vaivai ma le le mafai ona faʻamalositino, ma o loʻo i ai i le taimi nei e leai ni togafitiga faʻavavevave e avanoa mo 'pe a manaʻomia' faʻaoga e faʻaitiitia ai nei vaega. ”

"O le faʻamalosia o tagata gasegase o le PAH e sili atu le malosi o le ki lea i lo latou soifua maloloina faaletino ma le mafaufau," o le tala lea a Raymond L. Benza, MD, Faʻatonu o le Vaega o Faʻafomaʻi Faʻataʻitaʻi i le Ohio State University Wexner Medical Center. "O le taimi nei ma le suʻesuʻega o le RT234, o loʻo matou suʻesuʻeina lo matou gafatia e faʻamalosia le gaioiga faaletino pe a manaʻomia e se maʻi. Atonu o se la'asaga lelei tele lea i le tatou taua ma lenei fa'ama'i.”

O le su'esu'ega VIPAH-PRN 2b (RT234-PAH-CL202) o se su'esu'ega fa'atuputeleina o fuala'au e iloilo ai suiga tetele i fa'ailoga pe a mae'a le fa'aogaina o le RT234 i mataupu e iai le PAH. O loʻo faʻapea o le inhaled RT234 (vardenafil inhalation powder) e mafai ona maua ai se faʻamanuiaga faʻapitoa mo le faʻaaogaina o tagata mamaʻi ma le World Health Organization (WHO) Group 1 Pulmonary Hypertension (PH) (Pulmonary Arterial Hightension [PAH]) e faʻaleleia ai le malosi o le faamalositino ma le faʻatinoga i totonu. gaoioiga o le olaga i aso uma, fa'apea fo'i le fa'aitiitia o fa'ailoga fa'amalositino (fa'ata'ita'iga, dyspnea) ma o latou a'afiaga leaga i le lelei o le olaga.