I le i ai o le pancreatic tumors, o nisi o siama puipuia e talepe i lalo palatini faʻavae i molelaʻau e faʻaosoina ai le fausiaina o aano mafiafia, o se pa puipui i togafitiga, o se suʻesuʻega fou na maua.

Taʻitaʻia e tagata suʻesuʻe mai le NYU Grossman School of Medicine, o le suʻesuʻega e faʻataʻamilomilo i le mafiafia o le porotini meshwork e lagolagoina totoga ma fesoasoani e toe fausia aano ua faaleagaina. O alava polotini Collagen, o le vaega tele o le mata, e fa'aauau pea ona talepe i lalo ma suia ina ia fa'atumauina ai le malosi, ma o se vaega o le fa'amalologa o manu'a.

O suʻesuʻega talu ai na faʻaalia ai o sela puipuia e taʻua o le macrophages e saofagā i se gaioiga e taʻua o le desmoplasia, lea e mafua mai i le faʻalavelave faʻafuaseʻi ma le tele o le tuʻuina o collagen e faʻafefe ai le kanesa pancreatic. I lenei si'osi'omaga, o lo'o iloa fo'i macrophages e lofia ma talepe i lalo collagen e ala i le gaioiga a se polotini e ta'ua o le mannose receptor (MRC1).

Lomiga i luga o le initaneti Aperila 4 i le Taualumaga a le National Academies of Sciences, o le suʻesuʻega o loʻo i ai nei na maua ai o le collagen faʻaleagaina na faʻateleina le aofaʻi o arginine, o se amino acid lea e faʻaaogaina e le enzyme nitric oxide synthase (iNOS) e maua ai mea faʻapipiʻi e taʻua o ituaiga o le nitrogen reactive. (RNS). O lenei mea, i le isi itu, na mafua ai ona lata ane, lagolago stellate sela e fausia ai le collagen-based meshes i luga o tuma, fai mai le au tusitala suʻesuʻe.

"O a matou faʻaiʻuga na faʻaalia ai pe faʻafefea ona faʻaogaina e le pancreatic tumors macrophages i le fausiaina o pa puipui fibrotic," o le tala lea a le tusitala suʻesuʻe muamua o Madeleine LaRue, PhD. I le taimi o le suʻesuʻega, o LaRue o se tamaititi faʻauʻu i le fale suesue a le tusitala suʻesuʻe sinia Dafna Bar-Sagi, PhD, le S. Farber Polofesa o Biochemistry ma Molecular Pharmacology ma Sui Dean mo Saienisi i NYU Langone Health. "E mafai ona faʻaogaina lenei faʻavae mole e faʻafetaui ai suiga o le kanesa i totonu o le tino o loʻo siomia ai tuma," o le faʻaopoopo mai lea a LaRue.

O le kanesa o le pancreatic o le lona tolu lea o mafuaʻaga autu o maliu e fesoʻotaʻi ma le kanesa i le Iunaite Setete, faatasi ai ma le lima tausaga o le ola o le 10%. O le kanesa pancreatic e tumau pea ona faigata ona togafitia i se vaega tele ona o le tele o fesoʻotaʻiga o mea fibrotic i tafatafa o tuma. O lenei fesoʻotaʻiga e le gata e poloka ai le avanoa e ala i togafitiga, ae faʻamalosia ai le tuputupu aʻe malosi.

Mo le suʻesuʻega o loʻo iai nei, o faʻataʻitaʻiga na faʻaalia ai o macrophages na ola i ipu o meaʻai (aganuʻu), ma liua i totonu o latou tulaga e faʻapalepale i le kanesa (M2), na talepeina le tele o collagen nai lo macrophage e osofaʻia sela o le kanesa (M1). E le gata i lea, na faʻamaonia e le 'au i se faasologa o suʻega o M2 macrophages e maualuga atu le maualuga o enzymes e maua ai le RNS, pei o le iNOS.

Ina ia faʻamaonia nei suʻesuʻega i isumu ola, na faʻapipiʻi e le 'au ni sela stellate na "muaʻi fafaga" i collage, pe tausia i se tulaga e leʻi fafagaina, i totonu o itu o manu suʻesuʻe faatasi ai ma sela o le kanesa pancreatic. Na matauina e le au le 100 pasene le faateleina o le mamafa o alava collagen intra-tumoral i tuma e mafua mai i sela o le kanesa na totoina faatasi ma sela stellate na muai togafitia i le collagen.

O le mea taua, o le suʻesuʻega na faʻaalia mo le taimi muamua o macrophages latalata i sela o le kanesa pancreatic, e le gata e ave i totonu ma talepeina le tele o collagen e avea o se vaega o le scavenging mo polotini e fafagaina ai le tuputupu ae le masani, ae ua suia foi e le scavenging, ina ia latou malosi faiga faiga. (metabolism) ua toe fa'aogaina ma fa'ailoga mo le fa'atupuina o fibrotic.

"Na maua e le matou 'au se masini e fesoʻotaʻi ai le faʻaogaina o le collagen i le fausiaina o se siosiomaga e teteʻe togafitiga faʻataʻitaʻi i tuma o pancreatic," o le tala lea a Bar-Sagi. "Ona o lenei siʻosiʻomaga mafiafia o se mafuaʻaga tele e mafua ai le mataʻutia o le kanesa pancreatic, o se malamalama sili atu i sootaga i le va o le palatini ma le fausiaina o pa puipui o le a manaʻomia e faʻaleleia ai le togafitiga o lenei faʻamaʻi faʻaleagaina."

OA MEA E AVEA MAI LENEI TUSI:

Publishing online April 4 in the Proceedings of the National Academies of Sciences, the current study found that the degraded collagen increased the amount of arginine, an amino acid that is used by the enzyme nitric oxide synthase (iNOS) to produce compounds called reactive nitrogen species (RNS).
“As this dense environment is a major reason why pancreatic cancer is so deadly, a better understanding of links between protein scavenging and the building of protective barriers will be needed to improve the treatment of this devastating malignancy.
O le mea taua, o le suʻesuʻega na faʻaalia mo le taimi muamua o macrophages latalata i sela o le kanesa pancreatic, e le gata e ave i totonu ma talepeina le tele o collagen e avea o se vaega o le scavenging mo polotini e fafagaina ai le tuputupu ae le masani, ae ua suia foi e le scavenging, ina ia latou malosi faiga faiga. (metabolism) ua toe fa'aogaina ma fa'ailoga mo le fa'atupuina o fibrotic.