Togafitiga Fou e Faʻaitiitia ai le Mageso ma Hives mai Chronic Spontaneous Urticaria

A HOLD Fa'asa'oloto 3 | eTurboNews | eTN
Avatar a Linda Hohnholz

I lenei vaega 3 faʻataʻitaʻiga, ua faʻaopoopo e Dupixent i vailaʻau faʻamaʻi masani-o-tausiga e toetoe lava faʻaluaina le faʻaitiitia o le faʻaitiitia o le maʻi ma le urticaria sikoa faʻatusatusa i le tulaga-o-tausiga naʻo ia i le 24 vaiaso i tagata mamaʻi-naive e le pulea i antihistamines.

O faʻamaumauga e faʻamalosia ai le gafatia o le tulimataʻiina o le IL-4 ma le IL-13, faʻataʻitaʻiga autu o le ituaiga 2 mumu, i lenei faʻamaʻi faʻamaʻi lavelave.

Regeneron Pharmaceuticals, Inc. ma Sanofi i aso nei na faʻasalalau faʻamatalaga lelei mo Dupixent® (dupilumab) i tagata mamaʻi e maua i le urticaria tuusaʻo masani (CSU) o loʻo faʻaleagaina (ie, e leʻi togafitia muamua i le omalizumab). O le su'esu'ega taua na fa'aalia ai le fa'aopoopoina o Dupixent i vaila'au fa'apitoa-o-tausiga e fa'aitiitia ai le ma'i'u ma sulu ile 24 vaiaso pe a fa'atusatusa ile antihistamines na'o ia i lenei tulaga su'esu'e. O nei faʻaiʻuga o le a tuʻuina atu i le aso i se sauniga tuai i le 2022 American Academy of Allergy, Asthma and Immunology (AAAAI) Fonotaga Faaletausaga.

"E ui lava i faʻamaʻi faʻamaʻi masani, o le toʻatele o tagata gasegase e maua i le urticaria faʻafuaseʻi faʻafuaseʻi o loʻo faʻaauau pea ona tauivi ma le vevela tele, mu ma le tiga e fesoʻotaʻi ma hives ma fula i lalo o le paʻu, lea e mafai ona faʻalavelave tele ai o latou olaga i aso uma," o le tala lea a Marcus Maurer, MD, Polofesa. o Dermatological Allergology, Falemai mo Dermatology, Venerology ma Allergology i le Charité University of Medicine i Perelini, Siamani. "O nei faʻamalosiaga faʻaiʻuga na faʻaalia ai, i latou e le mafai ona maua faʻamaʻi faʻamaʻi ile antihistamines naʻo, o tagata gasegase na faʻaopoopoina le dupilumab na faʻaleleia faʻailoga ma faʻailoga ma sili atu le puleaina o latou faʻamaʻi."

O fa'ai'uga pito i luga mai le fa'ata'ita'iga fa'apitoa, lua-tauaso, placebo-pulea, lea na fetaui ma tulaga muamua ma fa'ai'uga tulaga lua i le vaiaso 24, na fa'asalalau ia Iulai 2021. Fa'amatalaga na tu'uina atu i le Fonotaga Fa'aletausaga a le AAAAI 2022 na fa'aalia ai o gasegase na fa'aopoopo Dupixent i tulaga masani. -o-tausiga antihistamines toetoe lava faaluaina le faʻaitiitia o le mageso ma le urticaria gaioiga faʻatusatusa i tulaga-o-tausiga naʻo (placebo) faʻatasi ai ma le faʻaleleia faifaipea i le 24 vaiaso. O nei gasegase na maua se:

• 63% fa'aitiitiga o le ma'ifu fa'atasi ma Dupixent fa'atasi ma le 35% fa'atasi ma le placebo, e pei ona fuaina i le 0-21 point fa'aitiitiga fa'aletonu (10.24 point fa'aitiitiga ma Dupixent versus 6.01 point fa'aitiitiga ma placebo, p<0.001), o le fa'ai'uga muamua i le US (fa'ai'uga lona lua i le EU).

• 65% faʻaitiitiga o le gaioiina o le urticaria (itch and hive) mamafa ma Dupixent versus 37% faʻatasi ma placebo, e pei ona fuaina i le 0-42 point urticaria activity scale (20.53 point reduction with Dupixent versus 12.00 point reduction with placebo, p<0.001), le fa'ai'uga muamua ile EU (fa'ai'uga lona lua ile US).

O le su'esu'ega na fa'aalia ai taunu'uga saogalemu e tutusa ma le fa'amatalaga saogalemu o Dupixent i ana fa'ailoga fa'amaonia fa'ama'i. Mo le 24-vaiaso o togafitiga, o fua faatatau o faʻalavelave faʻalavelave e masani ona tutusa i le va o le Dupixent ma placebo vaega (50% Dupixent, 59% placebo). O le fa'alavelave fa'afuase'i na tupu o fa'alavelave i le nofoaga o tui (11% Dupixent, 13% placebo).

Ole fa'aogaina ole Dupixent ile CSU o lo'o i lalo ole atina'e ile falema'i, ma ole saogalemu ma le aoga e le'i iloiloina atoatoa e so'o se pulega fa'atonutonu.

E uiga i le tusitala

Avatar a Linda Hohnholz

Linda Hohnholz

Faatonu sili mo eTurboNews fa'avae ile eTN HQ.

lesitala
Faasilasila i
mālō
0 faamatalaga
Manatu Faʻapena
Vaʻai manatu uma
0
E te alofa i ou mafaufauga, faamolemole taʻu mai.x
()
x
Fa'asoa i...